Heparin Hanlim Dosage/Direction for Use

Intraveneous injection or mixing with perfusion solution is used for extracorporeal circulation. Hypersensitivity should be checked before administration for large individual difference and maintenance dose should be fixed by checking coagulation time after each injection during the early stages of treatment. After usual use, maintain whole blood coagulation time as over 15-20 min but fix administration dose according to method and purpose of administration.
Extracorporeal Circulation (Blood Dialysis, Heart-Lung Machinery): Blood Dialysis: General Heparination: Before dialysis, 1000-5000 units should be injected after each dialysis, 1000-1500 units/hr continuously or intermittently should be injected.
Local Heparination: 1500-2500 units/hr should be adminsitered continuously and the action of heparin should be neutralized with protamine sulfate for intracorporeal perfusion.
Blood Perfusion by Heart-Lung Machine: Administer 150-300 units/kg and may add in accord to the need of the elongation of extracorporeal circulatory time. Neutralize action of heparin with protamine sulfate after extracorporeal circulation.
Continuous Intraveneous Therapy: Mix 1000-3000 units with 5% dextrose injection, normal saline or Ringer's solution. Inject about at a rate of 30 drops/min and infuse at the rate of 20 drops/min when the whole blood coagulation time is elevated 2-3 times the control value.
Intermittent Intraveneous Therapy: Initial Dose: 10,000 units followed by 5000-10,000 units every 4-6 hrs.
Subcutaneous Therapy: Intial Dose: 10,000-20,000 units in a concentrated solution injected SC of 8000-10,000 units in a concentrated solution every 8 hrs or 15,000-20,000 units in a concentrated solution every 12 hrs.
Anticoagulation in Blood Transfusion and Blood Samples: When heparin is used as an in vitro anticoagulant in blood transfusions, 400-500 units of heparin is usually added to 100 mL of whole blood. When heparin is used as an in vitro anticoagulant for blood samples 100 units is added to each 20-30 mL of whole blood.